Dermatomyositis Autoantibodies

Autoantibodies are associated with specific complications and findings:

Anti-Jo:

Antisynthetase syndrome consisting of interstitial lung disease, mechanic’s hands, Raynaud phenomenon, sclerodactyly, and arthritis.

Anti-Mi2 (directed against-helicase):

Acute onset disease, V-neck sign, and shawl rash

Anti- SRP (directed against signal recognition particle):

Severe myositis, resistant to treatment

Anti- MDA5 (melanoma differentiation-associated gene 5):

Severe cutaneous involvement, amyopathic dermatomyositis, and rapidly progressive ILD

Anti- TIF-1 gamma (transcription intermediary factor) /Anti-p155/140:

Malignancy

Anti-SAE (ubiquitin-like modifier activating enzyme):

Dysphagia, skin disease preceding myositis

Anti-NXP2 (nuclear matrix protein 2):

Calcinosis cutis